Ammonium Formate, Optima LC/MS Grade

Optima LC/MS Grade ammonium formate is widely used in liquid chromatography and mass spectrometry as a volatile buffer component. The reagent is indispensable in the analysis of compounds that require a neutral or slightly alkaline medium for effective ionization in the mass spectrometer source. Unlike acid modifiers, the ammonium formate salt creates mild separation conditions. The buffer capacity in the pH range of 6-7 preserves the native structure of some biomolecules, which degrades in acidic environments. At the same time, the volatility of the salt ensures that it does not settle in the ion source and does not cause contamination of the mass analyzer during long-term series of analyses. The product has a minimal level of metallic impurities. This parameter is critical for LC-MS, since even trace amounts of sodium, potassium, or iron can form adducts with analytes, generating additional peaks in the mass spectrum and making it difficult to identify compounds. The ammonium formate salt is a hygroscopic white crystalline powder. It is easily soluble in water, as well as in aqueous solutions of acetonitrile and methanol, which simplifies the preparation of mobile phases of any formulation. During heating, the salt decomposes into gaseous products, leaving no residue, which confirms its high purity.