Formic acid, Optima LC/MS Grade

Optima LC/MS Grade formic acid is a volatile organic modifier designed to be added to mobile phases during liquid chromatography with mass spectrometric detection. The reagent is widely used in proteomics, pharmaceutical quality control, analysis of pesticides and metabolites. The addition of formic acid to the mobile phase performs two key functions. Firstly, it serves as a source of protons, contributing to the formation of protonated [M+H]⁺ molecules in the positive ionization mode, which increases the sensitivity of mass spectrometric detection. Secondly, the acid suppresses the interaction of the main compounds with the free silanol groups of the stationary phase, which leads to a more symmetrical shape of the chromatographic peaks. The product has a minimal content of metallic impurities, controlled at the level of billionths, which prevents the formation of undesirable metallic adducts in the mass spectra. The volatility of formic acid makes it possible to use it in methods with mass spectrometric detection without the risk of contamination of the ion source.