Thermo Scientific Vanquish Neo Ultra High Performance Liquid Chromatography System

The Thermo Scientific Vanquish Neo modular platform is a chromatography system optimized for nano-, capillary-, and micro-flow liquid chromatography. This system is designed for laboratories performing highly sensitive liquid chromatography-mass spectrometry (LC-MS) analysis. The system is in demand in proteomic research, biopharmaceutical analysis, and high-throughput translational research. The pump section is equipped with ProFlow XR technology, providing active flow control and excellent retention time reproducibility across the entire flow rate range. The system generates pressures up to 1500 bar and adjusts the mobile phase flow rate from 1 nanoliter to 100 microliters per minute (the recommended operating range is 100 nanoliters to 100 microliters per minute). These characteristics allow the use of long analytical columns up to 75 micrometers in diameter, ensuring high resolution when separating complex peptide mixtures. The sampling module features a unique split-loop design, minimizing sample dispersion and reducing the risk of carryover between assays. Next-generation SmartInject technology enhances electrospray ionization stability, extends column life, and improves retention time accuracy. An automatic multi-stage needle wash function further reduces intersample carryover, which is especially important when working with trace concentrations of substances. A vial bottom detector ensures accurate sampling from a limited sample volume, eliminating the risk of blank injections and minimizing loss of valuable material. The column thermostat maintains temperatures from 5°C above room temperature to 80°C (depending on configuration). Hydraulic connections are made using tool-less Viper and nanoViper fittings, ensuring virtually zero dead volume and reliable sealing at high pressures. The system is controlled via the Vanquish User Interface, a touchscreen interface that allows local and remote monitoring of the instrument's status, initiation of diagnostic procedures, and execution of routine maintenance tasks using video instructions. A built-in method editor verifies the compatibility of specified parameters with installed consumables, preventing operator errors. The system seamlessly integrates with Thermo Scientific mass spectrometers, including triple quadrupoles for high-throughput quantitative analysis and orbital mass spectrometers for applications requiring maximum resolution and mass accuracy. The product is certified according to the ACT (My Green Lab) environmental standard, confirming the transparency of environmental impact information throughout the entire life cycle—from production to disposal.